Endogenous Depression


The endogenous depression is a type of depressive disorder greater than previously used to be seen as a distinct disorder, and very rarely diagnosed. Instead, today it is diagnosed and is also known as clinical depression , a disorder of the state mood of characterized by persistent and intense feelings of sadness for long periods of time. These feelings have a negative impact on the mood and the way an individual behaves , as well as the affection in different physical functions , including sleep and appetite..


What is endogenous depression?

It is a disease that manifests itself in different ways in the individual, it is the one that originates within the brain without the need for an external factor that generally produces it due to physiological changes that occur in this important organ.


What is endogenous depression?

Endogenous depression consists of a type of depression that arises in a person without an environmental or circumstantial stimulus that alters it, thus producing a depressive picture , in other words, they present a depressive picture for no apparent reasons.



The main characteristics of endogenous depression are the following:

  • It originates from genetic causes that cause metabolic alterations in the brain.
  • It appears without the need for the person to have suffered traumatic experiences .
  • It is known by the name of melancholy .
  • Its main signs are sadness and anguish .
  • People who suffer from it tend to be hostile and very irritable .
  • The age of onset of the disease is between 30 and 60 years .


It is important to remember that this type of depression occurs after birth or at an early age due to unwanted chemical changes in the brain . Often these patients suffer from biochemical hypercortisolism in which plasma cortisol and urinary steroid excretion are increased. These patients can be of any age group or gender , so this would not be a conclusive cause either.


The consequences of endogenous depression can be clearly seen in its symptoms . People at overall experience great difficulties to continue their normal lives . It is difficult for them from falling asleep to being able to relate properly with their family and friends. In recent years, this type of depression has been linked to heart problems as well as pain in different parts of the body that affect aspects of daily life. It is difficult for them to join work, family, and this produces a series of serious consequences in the life of the patient suffering from depression.

Symptoms of endogenous depression

The most common symptoms that can be observed in patients with endogenous depression are the following:

  • Persistent feelings of sadness or hopelessness.
  • Loss of interest in activities or hobbies that were previously enjoyable, including sex.
  • Tiredness and lack of motivation to do things.
  • Trouble concentrating, thinking, or making decisions.
  • Difficulty falling asleep or maintaining a pleasant sleep.
  • They are people who generally isolate themselves from the rest.
  • Sometimes they may have thoughts of suicide.
  • Frequent headaches
  • Muscle aches that prevent them from doing activities.
  • They may have a loss in their appetite or otherwise, they may be people who overeat.


In order to correctly diagnose endogenous depression, it must first be evaluated by a competent doctor who will have to ask a series of questions about the patient’s medical history . The patient must have at least four of the following symptoms and for more than two weeks : alteration of appetite, sleep, psychomotor activity, cognitive functioning, physical energy , loss of pleasure, feelings of guilt and suicidal thoughts.


The most common medications used to treat people with endogenous depression include selective serotonin reuptake inhibitors and selective serotonin and norepinephrine reuptake inhibitors.  These medications increase the levels of certain brain chemicals that result in a decrease in depressive symptoms.

Another treatment used to treat depression is psychotherapy , known as talk therapy , which involves meeting regularly with a therapist. This type of therapy can help the patient cope with their condition and any related problems. The two main types of psychotherapy that are used are cognitive behavioral therapy and interpersonal therapy.

Ultimately, electroconvulsive therapy can be done if symptoms do not improve with medication and therapy. It involves placing electrodes on the head that send pulses of electricity to the brain , which can help treat people with endogenous depression by changing chemical interactions in the brain.

Endogenous depression in men

Endogenous depression can also occur in men, although it is more difficult to diagnose as men tend to hide their symptoms mainly out of shame. Although depression occurs more frequently in women , are the men who commit as many suicides for this cause, why the male awareness about the importance of a diagnosis in time is so important.

How it differs from exogenous depression

Researchers used to distinguish between endogenous depression and exogenous depression by the presence or absence of an event that could cause stress before the onset of depression. The endogenous depression is emerging without the need that exists previously an episode of stress ou trauma . In other words, endogenous depression has no apparent external cause and can instead be caused mainly by genetic and biological factors . Exogenous depressionon the contrary, it happens after a stressful or traumatic event has occurred or occurred . This type of depression is commonly called “reactive” depression.

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