The diencephalon is a part of the brain that includes the thalamus and hypothalamus . It is the link between the nervous system and the endocrine system . The diencephalon receives signals from the nervous system and interprets the signals, then the pituitary gland , which largely controls the endocrine system, responds by excreting hormones .


What is the diencephalon?

It is a structure of great importance that is located in the internal part of the cerebral hemispheres and is formed by the thalamus, hypothalamus, subthalamus and epithalamus and is responsible for transmitting sensory information .


The diencephalon is one of the three main parts of the forebrain , the other two being the telencephalon and the hypothalamus. It is continuous with the midbrain and with the hypothalamus.

  • Characteristics of the diencephalon
  • Location of the diencephalon
  • Limits
  • Parties
  • Function
  • Diseases and injuries of the diencephalon

Characteristics of the diencephalon

The main characteristics of the diencephalon are the following:

  • It has in its interior some important structures of the human brain, such as the thalamus or the hypothalamus .
  • It is located between the cerebral hemispheres and the stem of the brain .
  • Fibers that travel to the cerebral cortex travel through it.
  • It represents only 2% of the total weight of the central nervous system.
  • It has an important role in the limbic system of the brain, and is involved in the visceral pathways and the endocrine system .
  • The diencephalon is a set of nuclei of gray matter.
  • It is a region of the brain that contains a large number of nuclei and structures
  • It contains bundles of white matter that establish multiple connections with different parts of the brain.
  • This region of the brain is the continuation of the midbrain .

Location of the diencephalon

The diencephalon is located below the corpus callosum and the fornix , joining on the sides with the hemispheres of the telencephalon . Two main portions are distinguished in it:  a phylogenetically younger dorsal , the thalamoencephalon , and a ventral , phylogenetically older, the hypothalamus, which is a superior vegetative center.


The diencephalon has the following limits:

  • Upper limit: it  is the subarachnoid space of the transverse cerebral fissure.
  • Lower limit: it is also part of the subarachnoid space.
  • Lateral limit: internal capsule.
  • Caudal limit: it is the plane that crosses the posterior commissure and the mammillary tubercles.
  • Cranial limit: it is the plane that is crossing the anterior commissure and the optic chiasm.
  • The entire medial surface of the diencephalon forms the wall of the third ventricle.


The main parts of the diencephalon include the hypothalamus , thalamus , epithalamus along with the pineal gland and subthalamus :

  • Thalamus : collaborates in sensory perception , regulates motor functions and controls sleep and wake cycles . It acts as a station for sensory information.  Before sensory information reaches the cortex of your brain, it first stops at the thalamus. Sensory information travels to the area that they specialize in dealing with that sensory information and then that information passes to the cortex for further processing. The thalamus also processes the information it receives from the cortex. It transmits that information to other parts of the brain and plays an important role in sleep and consciousness .
  • Hypothalamus : It is the control center for many autonomous functions through the release of hormones . It is responsible for maintaining homeostasis and blood pressure . When the hypothalamus recognizes an unforeseen imbalance, it establishes a mechanism to rectify that disparity. It also has effects on behavior.
  • Epithalamus : located in the posterior or lower area of ​​the diencephalon that includes the pineal gland, it helps the sense of smell and helps regulate the sleep-wake cycles. The pineal gland is an endocrine gland that secretes the hormone melatonin , which is believed to play an important role in regulating the circadian rhythms responsible for sleep cycles.
  • Subthalamus : a part of it is made of tissues of the midbrain. This area is interconnected with the basal ganglia structures that are part of the brain.

Also found within the diencephalon is the third ventricle, one of the four ventricles or cavities of the brain that are filled with cerebrospinal fluid.


The function of the diencephalon is to relay sensory information between regions of the brain and is responsible for controlling many autonomous functions of the peripheral nervous system . It also connects the structures of the endocrine system with the nervous system and works with the structures of the limbic system to generate and manage emotions and memories.

Various structures of the diencephalon work together and also with other parts of the body to participate in the following bodily functions:

  • Direct sensory impulses throughout the body
  • Control autonomous function
  • Endocrine function control
  • Control of motor function of the body
  • Regulates homeostasis
  • Participates in hearing, vision, smell and taste
  • Regulates tactile perception

Diseases and injuries of the diencephalon

The most common diseases of the diencephalon are:

  • Insomnia : or lack of sleep, it can affect when to fall asleep, to maintain it or to wake up in the morning. It is related to depression .
  • Thalamic syndrome : it is a strange neurological condition that damages the part of the brain that is responsible for controlling emotions . It produces an acute pain before slight stimuli or the diminution of the sensations .

Injuries occur at generally as a result of thrombosis or bleeding in the arteries that supply. An injury can cause a significant deterioration of sensations on the side of the body opposite to where the injury occurs. It can give a discrimination touch and a loss of appreciation of the movements in the joints .

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